Methyltestosterone

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Foshan Jiazhinuo Biotechnology Co.,Ltd

Business Type:Trader

Country/Region:China

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6/10

Product Information

Description

  

 

17a-Methyl-1-testosterone


Properties


Melting point: 162-168 °C(lit.)

Density 1.082

solubility H2O: ≤0.5 mg/mL

form solid (photosensitive)

color white


Abstract


17a-Methyl-1-testosterone can promote the male sex organs and used in seeding stage sex change. 17a-Methyl-1-testosterone is a steroid hormone from the androgen and is found in mammals and other vertebrates ,17a-Methyl-1-testosterone is primarily secreted in the tests of mails and the ovaries of female, although samll amount are also secreted by the adrenal glands , 17a-Methyl-1-testosterone is the principle male sex hormone and an anabolic steroid.


17alpha-methyl testosterone is a synthetic androgen with affinity for the androgen receptor. 17alpha-methyl testosterone is used widely as a component of hormone replacement therapy. Previous reports have indicated that contrary to testosterone, 17alpha-methyl testosterone is not aromatized. However, 17alpha-methyl testosterone still could affect local estrogen formation by regulating aromatase expression or by inhibiting aromatase action. Both possibilities have important clinical implications.


To evaluate the effect of 17alpha-methyl testosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. We found that in both cell lines, 17alpha-methyl testosterone inhibits aromatase activity in a dose-related manner. The curve of inhibition parallels that of letrozole and gives complete inhibition at 10(-4) M 17alpha-methyl testosterone, determined by the tritium release assay. 17alpha-methyl testosterone does not have detectable effects on aromatase RNA and protein expression by Jar cells. Undifferentiated THP-1 cells had no aromatase activity and showed no effect of 17alpha-methyl testosterone, but differentiated THP-1 (macrophage-like) cells had a similar inhibition of aromatase activity by 17alpha-methyl testosterone to that seen in Jar cells.


The Lineweaver-Burke plot shows 17alpha-methyl testosterone to be a competitive aromatase inhibitor. Our results show for the first time that 17alpha-methyl testosterone acts as an aromatase inhibitor. These findings are relevant for understanding the effects of 17alpha-methyl testosterone as a component of hormone replacement therapy. 17alpha-methyl testosterone may, as a functional androgen and orally active steroidal inhibitor of endogenous estrogen production, also offer special possibilities for the prevention/treatment of hormone-sensitive cancers.


Specification

TestAnalysis StandardResults

Description
White Or Almost White Crystalline Powder
White Crystalline Powder

Melting Point

223-225ºC

223-224ºC

Loss On Drying

≤0.5%

0.22%

Residue On Ignition

≤0.1%

0.05%

Assay

≥98%

98.32%

Conclusion

Be Conform With Enterprise Standard

The usage of Methyltestosterone

Use 17a-Methyl-1-testosterone as directed by your doctor. Check the label on the medicine for exact dosing instructions.Take 17a-Methyl-1-testosterone by mouth with or without food. If stomach upset occurs,take with food to reduce stomach irritation.If you miss a dose of 17a-Methyl-1-testosterone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Don’t take 2 doses at once.


Application


17-Alpha-Methyltestosterone can promote the male sex organs and used in seedling stage sex change.


17-Alpha-Methyltestosterone is a steroid hormone from the androgen and is found in mammals and other vertebrates,17-Alpha-Methyltestosterone is primarily secreted in the tests of mails and the ovaries of female, although small amount are also secreted by the adrenal glands, Methyltestosterone is the principle male sex hormone and an anabolic steroid.


17-Alpha-Methyltestosterone plays a key role in the development of male reproductive tissue such as the testis and prostates.


In addition, M1T is essential for health and well-being as well as the prevention of osteoporosis,17-Alpha-Methyltestosterone is conserved through most vertebrates, although fish make a slightly difference from called 11-ketotestosterone.



Dosage


When taking methyl 1-test, It is best to start out with at least a week at a dose of 5-10 mg to see how one reacts. Many users find this range to be effective, while others feel the ideal amount is 20-40 mg. It comes down to the experience, goals, and individual reaction. Many find a lower dose to be just as effective as a higher one, but with less side effects. With a compound such as this, it is generally best to err on the side of caution, especially for those that are less experienced with steroids. Most seem to find their ideal dose to be in the 10-30 mg range. Cycle length should be kept short, in the range of 1-4 weeks. Finally, it is especially important to take adequate time off after each cycle with this substance to allow the body to recover.



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